![]() No animal model has been reported for ALGS bleeding, and risk factors for bleeding have not been systematically addressed. It is currently not well understood why some patients experience spontaneous bleeds. Vascular defects in ALGS represent a significant burden of the disease (Hoffenberg et al, 1995 Emerick et al, 1999 Lykavieris et al, 2003 Kamath et al, 2004) and lead to transplant-associated complications (Kamath et al, 2004). However, up to 25% of deaths in these patients are attributed to intracranial hemorrhage (Emerick et al, 1999 Quiros-Tejeira et al, 1999 Kamath et al, 2004).
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